Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis

Inclusion Criteria: * ACR criteria fulfilled,DAS28-3(CRP \> 3.2 * \> 6 months prior treatment with infliximab 3 mg/kg i.v. every 8 week with initial response * Fading clinical response to infliximab * Negative pregnancy test (women with childbearing potential) * Use of reliable method of contraception (women with childbearing potential) * Informed consent Exclusion Criteria: * Age less than 18 years * Lack of co-operability * Positive serology for hepatitis B or C * History of positive HIV status * History of TB or untreated latent TB * Histoplasmosis or Listeriosis * Pregnancy or breastfeeding * Persistent or recurrent infections * History of cancer * Uncontrolled diabetes * Ischaemic heart disease * Congestive heart failure (NYHA 3-4) * Active inflammatory bowel disease * Recent stroke (within 3 months) * History of or current inflammatory joint disease other than RA * Previous diagnosis or signs of central nervous system demyelinating disease