Efficacy and Safety Study of Clozapine Augmented by Atomoxetine Versus Clozapine Augmented by Placebo in Patients With Chronic Resistant Schizophrenia

Inclusion Criteria: 1. Diagnosis of Schizophrenia that meets the diagnostic criteria as defined in the Diagnostic and Statistical Manual of Mental Disorders (4th edition, text revision) (DSM-IV-TR), APA 2000). 2. Adult (18-65) males or females with a confirmed primary diagnosis of schizophrenia. 3. Stable symptoms as determined by a score of 70 or less on the PANSS. 4. Women of child bearing potential must be using a medically accepted means of contraception. 5. Adequate cognitive function (IQ \> 65) as assessed by the WRAT3, with a level of understanding sufficient to perform all tests and examinations required by the protocol. 6. Considered reliable. 7. Stable on clozapine treatment. Criteria for stability defined as follows: * Patients should have been taking oral clozapine daily for the last 4 weeks (with no change in clozapine dose in the 4 weeks prior to screening). * Patients must not require chronic add-ons or have taken "as needed" antipsychotic or antidepressant medications in the last four weeks to control agitation, behavioral disturbance, or primary psychiatric symptomatology. * There must have been no significant change in the level of care required, caused by worsening of schizophrenia in the last four weeks. For example any escalation from lesser to greater intensity of treatment or ER visits. * Patients must not be taking any additional psychotropic medications including health food supplements judged by the investigator to be likely to have central nervous system activity (for example, St. John's Wort, ginkgo biloba leaf, melatonin). * Patients must not have received a depot antipsychotic within the past 8 weeks days. 8. Each patient must be judged competent and able to understand the nature of the study and must sign an informed consent document prior to participation in the study. 9. Patients must be able to swallow medications. Exclusion Criteria: 1. Clinically significant organic disease that, in the opinion of the investigator, would put the patient at significant risk from study procedures or interfere with data interpretability. This includes hepatic (specifically any degree of jaundice), renal, gastroenterologic, respiratory, cardiovascular (including ischemic heart disease), endocrinologic, neurologic, or immunologic conditions. 2. Potentially serious or unstable medical condition that is likely to require excluded medications or other significant treatment during the course of this treatment. 3. Patients who have not tolerated atomoxetine in the past or have history of clinically significant adverse effect(s) during prior treatment with atomoxetine. 4. Patients who have not tolerated oral CLZ in the past or experienced significant adverse effect(s) in the past. 5. History of non-response to clozapine (treatment refractory) defined as unambiguous lack of improvement despite contiguous adequate trial of at least 14 weeks of treatment. 6. Clozapine blood levels outside the optimum CLZ plasma levels of 350 to 400 ng/ml. 7. Women who are pregnant, breastfeeding, or refuse to use adequate birth control. 8. Significant risk of suicidal behavior or pose an imminent significant threat to others, at the time of screening. 9. History of alcohol or drug dependence (except nicotine and caffeine) that meets DSM IV criteria, within the past six months or have a history of drug or alcohol abuse within the past 30 days. Patients who have history of cannabis use for recreational purposes may be enrolled if in the opinion of the PI, the drug use pattern is not primarily related to a psychiatric condition or diagnosis. 10. Have abnormal blood pressure in the opinion of the investigator. 11. Electrocardiograms (ECGs) outside the normal limits. 12. Abnormal clinical laboratory test results outside the normal range. 13. History of agranulocytosis (absolute neutrophil count \<500 mm3). 14. Uncorrected hypothyroidism, hyperthyroidism or abnormal thyroid-stimulating hormone (TSH) concentrations. Patients previously diagnosed with hyperthyroidism or hypothyroidism who have been treated on a stable dose of thyroid supplement for at least 3 months, have medically appropriate TSH concentrations, and who are clinically euthyroid are allowed. 15. History of clinically significant head injury. 16. History of allergic reaction to clozapine or atomoxetine or any condition that could be aggravated by treatment with these medications (for example, narrow-angle glaucoma, urinary retention or hesitancy). 17. one or more seizures without a clear and resolved etiology. 18. Hearing or visual impairment severe enough to interfere with performance on cognitive tests. 19. Patients who have taken a monoamine oxidase inhibitor (MAOI) drug (for example Nardil™, Parnate™, or Eutron™ for depression) or tryptophan within the last 2 weeks prior to screening. 20. History of electroconvulsive therapy within the previous year. 21. History of mental retardation. 22. Have grade-level equivalent score of less than 8th grade as determined by WRAT3. This means that a patient must have a raw score of 40 or above (IQ equivalent of 81) in order to qualify. 23. Have received treatment within the last 30 days with a drug that has not received regulatory approval for any indication at the time of study entry. 24. Investigator site personnel directly affiliated with the study, or are immediate family of investigator site personnel directly affiliated with the study. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted. 25. Patients who, in the opinion of the investigator, are unsuitable in any way to participate in this study.