Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma

Inclusion Criteria: * Provide written informed consent prior to study-specific screening procedures, with the understanding that the patient has the right to withdraw from the study at any time, without prejudice. * Age \>18 years * Ambulatory outpatients (if applicable), with Karnofsky performance status of \>60 * Histologically or cytologically confirmed locally advanced nonmetastatic T3-4 N0-3 M0 carcinomas of the rectosigmoid. * Surgical exploration without resection is permissible. * Protocol Specific Laboratory Values as defined in section 4.2 * Has a negative serum pregnancy test within 7 days prior to start of therapy (female patients of childbearing potential). * Have concomitant medications been reviewed with patient to address contraindicated medications described in section 7.8 and have precautions been taken as recommended for each drug? Includes Allopurinol, Cimetidine, Sorivudine and Brivudine, Anticoagulants, Phenytoin, and Laxatives. Exclusion Criteria: Patients who fulfill any of the following criteria will be excluded: * Pregnant or lactating woman. Woman of childbearing potential with either a positive or no pregnancy test at baseline. Woman or men of childbearing potential not using a reliable and appropriate contraceptive method. (Postmenopausal woman must have been amenorrheic for at least 12 months to be considered of non-childbearing potential). Patients will agree to continue contraception for 30 days from the date of the last study drug administration * Life expectancy \< 3 months. * Serious, uncontrolled, concurrent infection(s). * Prior unanticipated severe reaction to fluoropyrimidine therapy, or known sensitivity to 5-fluorouracil, or known DPD deficiency. * Completion of previous chemotherapy regimen \< four weeks prior to the start of study treatment, or with related toxicities unresolved prior to the start of study treatment. * Treatment for other carcinomas within the last five years, except cured non-melanoma skin and treated in-situ cervical cancer. * Participation in any investigational drug study within 4 weeks preceding the start of study treatment. * Clinically unstable cardiac disease (e.g. congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmias not well controlled with medication) or myocardial infarction within the last 12 months. * Evidence of metastases or history of uncontrolled seizures, central nervous system disorders or psychiatric disability judged by the investigator to be clinically significant, precluding informed consent, or interfering with compliance of oral drug intake. * Other serious uncontrolled medical conditions that the investigator feels might compromise study participation. * Major surgery within 4 weeks of the start of study treatment, without complete recovery (e.g., delayed wound healing). * Lack of physical integrity of the upper gastrointestinal tract or malabsorption syndrome. * Known, existing uncontrolled coagulopathy * Any of the following laboratory values: * Abnormal hematologic values (neutrophils \< 1.5 x 109/L, platelet count \< 100 x 109/L) * Impaired renal function (estimated creatinine clearance \<30ml/min as calculated with Cockroft-Gault equation. * Note: In patients with moderate renal impairment (estimated creatinine clearance 30-50 mL/min) at baseline, a dose reduction to 75% of the capecitabine starting dose is recommended. * Serum bilirubin \> 1.5 x upper normal limit. * ALT (SGOT), AST (SGPT) \> 2.5 x upper normal limit (or \> 5 x upper normal limit in the case of liver metastases). * Alkaline phosphatase \> 2.5 x upper normal limit (or \> 5 x upper normal limit in the case of liver metastases or \> 10 x upper normal limit in the case of bone disease) * Unwillingness to give written informed consent or HIPAA privacy authorization. * Unwillingness to participate or inability to comply with the protocol requirements for the duration of the study. * Patient taking a contraindicated medication(s) described in section 6.2.8 (see inclusion criteria #8 for list of agents) and no appropriate substitute agent is available, or patient unable or refuses to take substitute agent.