Patients with psoriasis vulgaris of the trunk and/or limbs are randomised to treatment with: 1. 4 weeks of ointment containing calcipotriol and betamethasone dipropionate followed by 8 weeks of calcipotriol cream 2. 4 weeks of (calcipotriol plus betamethasone dipropionate) ointment followed by 8 weeks of calcipotriol cream on weekdays/ (calcipotriol plus betamethasone dipropionate) ointment on weekends 3. 4 weeks of (calcipotriol plus betamethasone dipropionate) ointment followed by 8 weeks of vehicle of calcipotriol cream The objective is to compare the efficacy and safety of the different treatment regimens
A phase IV study of different treatment regimens of calcipotriol 50 mcg/g cream and combination (calcipotriol 50 mcg/g plus betamethasone 0.5 mg/g (as dipropionate)) ointment following treatment with combination ointment in psoriasis vulgaris
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
1,032
Universitair Ziekenhuis
Ghent, Belgium
Dermatrials Research Dermatology Centre
Hamilton, Ontario, Canada
Hôpital Nord, Service de Dermatologie
Saint-Etienne, France
Klinikum der Goethe-Universität, Zentrum für Dermatologie und Venerologie
Frankfurt, Germany
Canisius-Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Hospital Mutua de Terrassa Dermatology Service
Terrassa, Spain
Clatterbridge Hospital, Department of Dermatology
Merseyside, United Kingdom
Efficacy of regimen (a) versus regimen (c) by % change in PASI at week 12
Efficacy of regimen (b) versus regimen (c) at week 12, safety of regimen (a) versus (c), safety of regimen (b) versus (c)
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