The study aim is to compare a balanced anesthesia of the medicines used in all other age groups with the routine premedication in use for premature's with regards to the success in the intubation procedure, the need for analgesia during and after intubation and the stress reaction. In addition a pain scale for prolonged stress/pain for premature neonates in NICU-care will be validated, and the individual pharmacogenetic profile in relation to the need of morphine after the intubation will be investigated. The hypothesis is that balanced anesthesia before intubation facilitates the procedure, decreases the amount of stress and pain related to it, and causes a decreased need for analgesia after the intubation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
Premedication with atropine 0.02 mg/kg and morphine 0.03 mg/kg
Premedication with glycopyrronium 0.005 mg/kg, thiopental 2-3 mg/kg (\< 2 kg 2 mg/kg), suxamethonium 2 mg/kg and remifentanil 0.001 mg/kg
Neonatal Departement Lund University Hospital
Lund, Sweden
Success of intubation according to a specific score including duration of the procedure and changes in oxygen saturation, blood pressure and heart rate during the intubation
Time frame: 6-9 months
Pain score at intubation
Time frame: 6-9 months
Biochemical stress/pain response
Time frame: 6-9 months
Physiological stress/pain response
Time frame: 6-9 months
Behavioural stress/pain response
Time frame: 6-9 months
Neurophysiological stress/pain response (aEEG)
Time frame: 6-9 months
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