Effect of Yohimbine on Colon Transit

Mayo Clinic30 enrolled

Overview

This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed at which food travels through the stomach, intestines and colon, and if yohimbine affects the amount of liquid you can drink in a short period of time. Understanding how yohimbine works on the gut may help develop new treatments for patients with constipation. Yohimbine has been approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed in this study is considered investigational.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy Volunteers

Interventions

Yohimbine, oralDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

* Healthy male or non-pregnant, non-breastfeeding female volunteers, -18-65 years old; * Able to provide written informed consent before participating in the study; * Able to communicate adequately with the investigator and to comply with the requirements for the entire study.

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Colonic transit

Secondary Outcomes

Small bowel transit time

Gastric emptying time

Maximum tolerated volume ingested during satiation testing

Average stools per day

Stool consistency

Data from ClinicalTrials.gov

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