Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent Individuals

Inclusion Criteria: * Meets DSM-IV criteria for current cocaine dependence * Not currently seeking treatment for cocaine dependence * Currently uses cocaine, as determined by a self-report and a positive urine test for cocaine, within 30 days prior to study entry * Within 20 % of ideal body weight, and weighs at least 100 lbs * Good general health * Normal electrocardiogram * Willing to use acceptable methods of contraception for the duration of the study Exclusion Criteria: * Current or history of a major psychiatric illness, other than drug dependence or disorders secondary to drug abuse * Meets DSM-IV criteria for dependence on any drugs other than cocaine, marijuana, nicotine, or alcohol * Physiologically dependent on alcohol and requires medical detoxification * Use of prescription drugs within 14 days prior to study entry * Use of non-prescription drugs within 7 days prior to study entry * If female, used an oral contraceptive, Depo-Provera, Norplant, or intrauterine progesterone contraceptive system, within 30 days prior to study entry * Pregnant or breastfeeding * History of liver disease * Current elevated aspartate aminotransferase or alanine aminotransferase levels * Donated a unit of blood within 4 weeks prior to study entry * Participated in any other clinical investigation within 4 weeks prior to study entry * History of any illness or behavior that, in the opinion of the investigator, might interfere with the study * Family history of early significant cardiovascular disease * Exhibits Hepatitis B surface antigen or Hepatitis C antibody * HIV infected * Syphilis * Active tuberculosis * Adult asthma * Chronic obstructive pulmonary disease * Unable to distinguish between 20 mg and 40 mg of intravenous cocaine