Naltrexone Augmentation of Nicotine Patch Therapy - 1

Inclusion Criteria: 1. Age 18 and older 2. Willingness and ability to give written consent 3. Smoking 20 cigarettes per day for at least 1 year 4. At least one prior attempt to stop smoking 5. Baseline expired carbon-monoxide level of at least 10 ppm 6. Weigh at least 100 lbs. 7. English speaking 8. One person per household Exclusion Criteria: 1. Pregnant or nursing women or women who do not use a reliable form of birth control 2. Unstable cardiac disease 3. History of dermatoses 4. Current alcohol dependence 5. Current use of opiates 6. A urine drug screen that is positive for opiates 7. Serious current neurologic, psychiatric or medical illness 8. Chronic pain conditions necessitating opioid treatment 9. Evidence of significant hepatocellular injury as evidence by SGOT or SGPT \>3 x normal or elevated bilirubin 10. Current use of smokeless tobacco, pipes, cigars, nicotine gum or nicotine patch 11. Patients requiring concomitant therapy with any psychotropic drug or on any drug with a psychotropic component