Exercise-training Before Coronary Artery Bypass Graft (CABG)

Norwegian University of Science and Technology40 enrolled

Overview

The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Angina Coronary Artery Disease

Interventions

Exercise trainingBEHAVIORAL

Intensity controlled exercise training before the scheduled bypass surgery

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled for CABG both with and without heart failure Exclusion Criteria: * Unstable angina * Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group) * Participation in another study

Locations (1)

Norwegian University of Science and Technology

Trondheim, Norway

Outcomes

Primary Outcomes

Cardiovascular function and quality of life

Time frame: Before and up to 1 year after intervention

Secondary Outcomes

Structure and function of cardiomyocytes

Time frame: After the intervention period

Cardiomyocyte structure and function

Time frame: after the intervention period

Data from ClinicalTrials.gov

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