Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

N/AUnknownNCT00220246

Radboud University Medical Center130 enrolled

Overview

Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Colorectal Neoplasms

Eligibility

Sex: ALLMax age: 51 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Colorectal cancer before the age of 51 years Microsatellite stable tumor Exclusion Criteria: \-

Locations (1)

Radboud University

Nijmegen, Netherlands

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.