Perioperative Epidural Trial (POET) Pilot Study

University of British Columbia250 enrolled

Overview

To investigate if the use of perioperative neuraxial blockade reduces post-operative mortality and cardiorespiratory events compared to intraoperative general anesthesia AND postoperative IV narcotic analgesia. This is a feasibility study to determine if recruitment and execution of the protocol could be done in a timely manner in a much larger trial

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

250

Conditions

Post Operative Pain Control

Interventions

anesthesiaPROCEDURE

Intraoperative general anesthesia AND postoperative IV narcotic analgesia.

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: Subjects at high risk of cardio-respiratory complications post operatively. Exclusion Criteria: Contraindication to epidural anesthesia

Locations (1)

Vancouver General Hospital, Clinical Health Research Unit

Vancouver, British Columbia, Canada

Outcomes

Primary Outcomes

Combined mortality, MI, cardiac arrest, post operative pneumonia , and respiratory failure

Secondary Outcomes

DVT, pulmonary embolism, TIA, CVA, CHF, clinically significant bradycardia/hypotension

Data from ClinicalTrials.gov

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