Proper Dosage of Ketamine in Intravenous Regional Anesthesia

University Health Network, Toronto

Overview

Ketamine added to Lidocaine can increase duration of pain relief following intraveonous regional anesthesia (IVRA). The purpose of this dose response study is to determine the minimum effective dosage of intravenous Ketamine, added to 3 mg/kg of Lidocaine. We anticipate that one dosage will provide us with the proper balance between sufficient anesthesia and minimal side effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Pain.

Interventions

Different dosages of KetamineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: 18-70 2. Weight: 50-100 kg 3. ASA: I, II, III 4. Carpal tunnel syndrome surgery, tenolysis, ganglion removal or any peripheral hand surgery that can be done by IVRA. Exclusion Criteria: 1. Contraindication to IVRA such as sickle cell disease. 2. Any known hypersensitivity reaction to Ketamine. 3. History of chronic pain or regular medication with analgesics. 4. History of opioid dependence. 5. Drug of alcohol abuse. 6. Psychiatric disorder. 7. Allergy to acetaminophen or codeine

Locations (1)

University Health Network

Toronto, Ontario, Canada

RECRUITING

Central Contacts

Colin McCartney, MD

CONTACT

(416)603-5118 colin.mccartney@uhn.on.ca

Data from ClinicalTrials.gov

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