In this study the researchers want to investigate genetic polymorphisms of cytochrome 450 enzymes and the multiple drug resistance (MDR) gene in renal transplant patients to look for differences in dosing of immunosuppressive drugs (tacrolimus, sirolimus, everolimus, cyclosporine A). All patients who receive one of these drugs can be included and drug blood trough levels, dosing and genetics are compared.
Primary endpoint is the 1. serum creatinine in patients with and without polymorphysms 2. rate of rejections in patients with and without polymorphysms
Study Type
OBSERVATIONAL
Enrollment
200
retrospective analyze of drug levels in comparison to polymorphism
retrospective of drug blood trough levels in comparison to polymorphism of enzymes of drug metabolism
retrospective of drug blood trough levels in comparison to polymorphism of enzymes of drug metabolism
University of Schleswig-Holstein, Campus Kiel, Department of Nephrology
Kiel, Germany
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retrospective of drug blood trough levels in comparison to polymorphism of enzymes of drug metabolism