Cytokine Regulation of Periradicular Pain in Humans

The University of Texas Health Science Center at San Antonio9 enrolled

Overview

This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis

This study evaluates whether periradicular exudate concentrations of cytokines differ in patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute exacerbation of a chronic apical periodontitis, as compared to patients with pulpal necrosis with chronic apical periodontitis, but no pain or mechanical allodynia

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Apical Periodontitis of Pulpal Origin

Eligibility

Sex: ALLMin age: 16 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient must be at least 16 years of age. 2. Clinical indication for Non-Surgical Root Canal Therapy (NSRCT). 3. 1st or 2nd maxillary or mandibular molar 4. Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms. 5. Intact, mature apices. 6. ASA I or II Exclusion Criteria: 1. Failure to meet any of the above 2. Previous NSRCT 3. Previous pulpotomy or pulpectomy 4. Suppurative apical periodontitis 5. Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)

Locations (1)

Univerity of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.