Methylphenidate and Driving Ability in Adult Patients With Attention-Deficit Hyperactivity Disorder

Utrecht Institute for Pharmaceutical Sciences18 enrolled

Overview

The primary purpose of this study is to determine the effects of methylphenidate versus placebo on driving ability of adult ADHD patients.

This study was set-up to examine the controversial issue whether or not it is safe to drive a car or not when treated with methylphenidate. On-the-road driving tests during normal traffic are conducted to determine the effects of methylphenidate versus placebo on driving ability of adult ADHD patients.In addition, two laboratory tests are conducted to examine memory functioning and inhibitory control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

ADHD

Interventions

methylphenidateDRUG

Eligibility

Sex: ALLMin age: 21 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult ADHD patient over 21 years old * valid driver's license for at least 3 years * treated with methylphenidate * written informed consent Exclusion Criteria: * use of illicit drugs * use of drugs or having medical conditions known to affect driving ability

Locations (1)

Utrecht Institute for Pharmaceutical Sciences

Utrecht, Netherlands

Outcomes

Primary Outcomes

Driving test:Standard Deviation of Lateral Position (SDLP, cm);i.e. the weaving of the car [single dose effects]

Secondary Outcomes

Other Driving test parameters: Standard Deviation of Speed, mean speed, mean lateral position.

Memory test: immediate & delayed word recall, delayed recognition.[single dose effects]

Continuous Performance test: RT, %errors [single dose effects]

Data from ClinicalTrials.gov

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