KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

Assistance Publique - Hôpitaux de Paris80 enrolled

Overview

We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the central nervous system involved in this chronic neuropathic pain.

In this clinical, randomized prospective study, peri operative administration of ketamine was compared to placebo on long term post thoracotomy pain after a 2 months follow up period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Ketamine Chronic Post Thoracotomy Pain Thoracotomy Pain Neuralgia

Interventions

Ketamine (or placebo : isotonic saline solution)DRUG

Eligibility

Sex: ALLMin age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients eligible for thoracotomy or pneumectomy Exclusion Criteria: \-

Locations (1)

Georges Pompidou European Hospital

Paris, Île-de-France Region, France

Outcomes

Primary Outcomes

Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups

Secondary Outcomes

Analogic pain scores at rest and after coughing

Data from ClinicalTrials.gov

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