CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome

Assistance Publique - Hôpitaux de Paris80 enrolled

Overview

The aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with HNPCC syndrome, compared to a routine colonoscopy without chromoscopy.

Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the study. Patient have 2 colonoscopy back to back. The second coloscopy is associated to chromoscopy with carmin indigo. Endoscopist are randomised for the colonoscopy with chromoscopy and are un-awarded of the result of the first colonoscopy. Histopathology of the polyp are noted. The follow up were 1 month.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Colorectal Neoplasms, Hereditary Nonpolyposis

Interventions

Colonoscopy with chromoscopyPROCEDURE

Eligibility

Sex: ALLMin age: 25 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with MLH1, MSH2 or MSH6 mutation. * Patients concerned by early detection colonoscopy. Exclusion Criteria: * Coloscopy of tracking since less 1an * occlusive Syndrome contra-indicating the preparation for a total coloscopies * Colectomies * medical Conditions or serious illnesses contra-indicating a coloscopy of screening * pregnant Woman or nursing * Anomaly of coagulation contra-indicating the realization of biopsies and/or the exeresis of the lesion colorectal

Locations (1)

Hopital Europeen Georges Pompidou

Paris, Île-de-France Region, France

Outcomes

Primary Outcomes

Number of pre-cancer lesions or early cancer detected.

Time frame: during the procedure

Secondary Outcomes

Anatomopathologic criteria (size of lesions, …).

Time frame: during the procedure

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.