In Stent ELUTES Study

Inclusion Criteria: * Patient has given informed consent * Patient has target lesion in native coronary artery or coronary bypass graft * Patient has in-stent restenosis \>60% * Patient has reference artery diameter 2.7-3.5 * Patient agrees to return for clinical assessment at 1, 6, 9, 12 and 24 months and for a treadmill test at 9 months and an angiogram at 9 months and 24 months. Exclusion Criteria: * Patient is less than 18 years of age * Patient is pregnant or breast feeding * Patient has history of bleeding diathesis or coagulopathy or will refuse blood transfusions. * Patient is simultaneously participating in another investigative interventional cardiovascular drug or device study. * Patient has known hypersensitivity or contraindication to aspirin or stainless steel or a sensitivity to contrast agent.