Study of Blood Platelets in Sickle Cell Disease

Rockefeller University

Overview

We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.

Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.

Study Type

OBSERVATIONAL

Conditions

Sickle Cell Disease

Eligibility

Sex: ALLMin age: 7 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults and children \> 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy. Exclusion Criteria: * Current hydroxyurea therapy or, * Hydroxyurea use within the past 3 months * Blood transfusion or exchange transfusion within the past 3 months * Current treatment with aspirin or clopidogrel

Locations (1)

Rockefeller University Hospital

New York, New York, United States

Data from ClinicalTrials.gov

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