Natural Supplements for Unipolar Depression

Cambridge Health Alliance20 enrolled

Overview

This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.

The study is 6 weeks long, with 9 clinical visits. All visits will take place at our location in Massachusetts.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Unipolar Depression

Interventions

Supplements of L-methionine, betaine and folateDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * DSM-IV diagnosis of a MDD or DDNOS; clinical indication for treatment of current depressive symptoms; HDS \> 18; women of reproductive potential must use an acceptable method of birth control Exclusion Criteria: * Treatment with another psychotropic drug; history of mania or hypomania; history of bipolar illness in first-degree relatives; active homicidality; pregnant; trying to become pregnant, or nursing; unstable medical condition; current substance abuse in the past month; history of sulfa allergy

Locations (1)

Cambridge Health Alliance

Cambridge, Massachusetts, United States

Outcomes

Primary Outcomes

Depressive symptoms

Data from ClinicalTrials.gov

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