RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Chemotherapy drugs may have different effects in older patients. PURPOSE: This phase II trial is studying how well docetaxel works in treating older patients with locally advanced or metastatic non-small cell lung cancer.
OBJECTIVES: Primary * Determine the quality of life of older patients with locally advanced or metastatic non-small cell lung cancer treated with docetaxel. Secondary * Determine the response rate in patients treated with this drug. * Determine the overall survival and progression-free survival of patients treated with this drug. * Determine the mood status and autonomy of activity of patients treated with this drug. * Determine the toxicity of this drug in these patients. OUTLINE: This is a multicenter study. Patients receive docetaxel IV twice in week 1. Treatment repeats every 2 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity. Quality of life is assessed during study therapy in weeks 3-4, 7-8, and 11-12, and then at 6 and 12 months after completion of study treatment. PROJECTED ACCRUAL: A total of 58 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Enrollment
58
Centre Medico-Chirurgical de Creil
Creil, France
Centre de Lutte Contre le Cancer Georges-Francois Leclerc
Dijon, France
Centre Hospitalier Intercommunal St. Aubin les Elbeuf
Elbeuf, France
Quality of life
Response rate
Overall survival
Progression-free survival
Mood status and autonomy of activity
Toxicity
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Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
Marseille, France
Institut Curie Hopital
Paris, France
Clinique De Genolier
Genolier, Switzerland
Charing Cross Hospital
London, England, United Kingdom
Centre for Cancer Research and Cell Biology at Belfast City Hospital
Belfast, Northern Ireland, United Kingdom
West of Scotland Cancer Centre
Glasgow, Scotland, United Kingdom