Effect of Paroxetine on COAT-Platelet Production in Normal Volunteers and Patients With Cardiovascular Disease

University of Oklahoma25 enrolled

Overview

COAT-platelets stands for collagen and thrombin stimulated platelets, which are two things in the body that make platelets stick together. These platelets may be important in the initiation of a heart attack (myocardial infarction). A chemical in the body called serotonin maybe responsible for COAT-platelet production. Paroxetine causes a significant reduction in platelet serotonin and therefore may have value in preventing heart attacks. Therefore, the current study is designed to determine whether paroxetine will decrease COAT-platelet production in normal volunteers and patients with cardiovascular disease.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Coronary Artery Disease

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * normal volunteers (without heart disease) * patients with heart disease * between ages 18 \& 65 Exclusion Criteria: * children less than 18 years * adults greater than 65 years * those who can not keep appointments * patients within 2 weeks of a coronary catheterization * patients within 6 months of unstable angina or myocardial infarction * individuals with allergies to paroxetine or similar medications * individuals having adverse events to paroxetine or similar medications * individuals with diagnosis of mania * individuals with a diagnosis of hypomania * individuals with a diagnosis of bipolar disorders * individuals with a diagnosis of depression * individuals with a diagnosis of panic disorders * individuals with a diagnosis of seizure disorders * individuals with a history of suicide attempts * individuals with a diagnosis of hyponatremia * individuals with active bleeding disorders * individuals with a diagnosis of narrow angle glaucoma * individuals with an estimated creatinine clearance of less that 30 ml/min * individuals taking potentially interacting medications

Outcomes

Primary Outcomes

To define the percent COAT-platelet and response to Paxil-CR in 5 control subjects.

Secondary Outcomes

To define the percent COAT-platelet and response to Paxil-CR in 20 patients with Coronary Artery Disease.