Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery

Institute of Child Health

Overview

The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children. We are testing the hypothesis that laparoscopic fundoplication is associated with a lack of hypermetabolism and catabolism and blunting of the endocrine/inflammatory stress response

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Gastro-Oesophageal Reflux

Interventions

Laparoscopic fundoplicationPROCEDURE

open Nissen fundoplicationPROCEDURE

Eligibility

Sex: ALLMin age: 1 MonthMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * infants and children with gastro-oesophageal reflux Exclusion Criteria: * septic shock, multi-organ dysfunction syndrome, cardiac, renal or congenital metabolic abnormalities

Locations (1)

Great Ormond Street Hospital and the Institute of Child health

London, United Kingdom

Outcomes

Primary Outcomes

resting energy expenditure

Secondary Outcomes

whole body protein turnover

indices of inflammatory response

pro and anti inflammatory cytokines

free radical production

post operative pain

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.