PiCCO Guided Therapy in Liver Cirrhosis

Heidelberg University20 enrolled

Overview

Prospective comparison of standard therapy in liver cirrhosis versus standard therapy plus intensified hemodynamic monitoring using the PiCCO system.

Patients presenting with advanced liver cirrhosis will receive either standard treatment or standard treatment plus hemodynamic monitoring with the PiCCO device. Fluids and vasoacitve drugs will be administered according to the measurements over a period of 5 days.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Liver Cirrhosis

Interventions

Hemodynamic monitoring system PiCCOPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Liver cirrhosis Child-Pugh-Score \> 7 * Ascites \> 500 ml Exclusion Criteria: * Coronary heart disease * Apoplexia \< 6 months ago * Vasculitis * Thrombosis * Arterial occlusive disease \> stadium II

Locations (1)

University of Heidelberg, Clinical center

Heidelberg, Germany

Outcomes

Primary Outcomes

Survival

Secondary Outcomes

Renal complications

Length of intensive care

Change in APACHE II

Data from ClinicalTrials.gov

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