Evaluation of Two Reduced Sirolimus Doses in Treatment of de Novo Coronary Artery Lesions (REDOX)

Inclusion Criteria: 1. Male or non-pregnant female patient minimum 18 years of age 2. No significant (\>50%) untreated stenoses proximal or distal to the target lesion that will not be treated during the procedure and may require revascularization or impede runoff; 3. Target lesion is 18mm in length (visual estimate); 4. Target lesion is 3.0mm and 3.5mm in diameter (visual estimate); 5. Target lesion stenosis is \>50% and \<100% (visual estimate); Exclusion Criteria: 1. A Q-wave or non-Q-wave myocardial infarction within the preceding 72 hours unless the CK and CK-MB enzymes are back to normal; 2. Ejection fraction 30%; 3. Stent placement of target lesion covers a side branch \>2.0mm in diameter;