Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment.

Inclusion Criteria: * Patients with the second and subsequent attack of recurrent pericarditis, * Age≥ 18 years, * Informed consent. Exclusion Criteria: * Suspected neoplastic, tuberculous, or purulent etiology, * Known severe liver disease and/or elevated transaminases \>1.5 times the upper limit of normality, * serum creatinine\>2.5 mg/dl, * Serum CK over the upper limit of normality or Known myopathy, * Known gastrointestinal or blood disease, * Pregnant or lactating women or women not protected by a contraception method, * Known hypersensibility to colchicine, * Treatment with colchicine at the enrolment.