The REALITY Study - Head-to-Head Comparison Between Cypher and Taxus

Inclusion Criteria: 1. Diagnosis of angina pectoris as defined by Canadian Cardiovascular Society Classification (CCS I, II, III, IV) OR unstable angina pectoris (Braunwald Classification B\&C, I-II-III) OR patients with documented silent ischemia; 2. Treatment of up to two de novo native coronary artery lesions in a maximum of two major coronary arteries; 3. Ostial lesions; 4. Bifurcations; 5. Target vessel diameter of both lesions must be \>=2.25mm and \<=3.0mm in diameter (visual estimate); 6. One target lesion must be at least 15 mm in length and the second lesion has to be at least 10 mm in length with no upper limit on either; 7. Target lesion stenosis for both lesions is \>50% and \<100% (visual estimate). Exclusion Criteria: 1. Patient has experienced a Q-wave or non-Q-wave myocardial infarction with documented total CK \>2 times normal within the preceding 72 hours and the CK and CK-MB enzymes remain above normal at the time of treatment; 2. Has unstable angina classified as Braunwald A I-II-III; 3. Any of the lesions is an unprotected left main coronary disease with \>=50% stenosis; 4. Angiographic evidence of thrombus within target lesion; 5. Heavily calcified lesion and/or calcified lesion, which cannot be successfully predilated (applies to both lesions); 6. Documented left ventricular ejection fraction \<=25%; 8\. Totally occluded vessel (TIMI 0 level) (applies to both lesions); 9\. Prior stent within 10mm of target lesion (applies to both lesions).