The Arterial Revascularization Therapies Study Part II.

Inclusion Criteria: 1. Patients with stable (Canadian Cardiovascular Society 1, 2, 3 or 4) or unstable (Braunwald class IB, IC, IIB, IIC, IIIB, IIIC) angina pectoris and ischemia, or patients with atypical chest pain or even those who are asymptomatic provided they have documented myocardial ischaemia (e.g. treadmill exercise test, radionuclide scintigraphy, stress echocardiography, Holter tape); 2. Patients who are eligible for coronary revascularization (angioplasty or CABG); 3. At least 2 lesions (located in different vessels and in different territories) potentially amenable to stent implantation; 4. de novo native vessels; 5. Multivessel disease with at least one significant stenosis in LAD and with treatment of the lesion in another major epicardial coronary artery. A two-vessel disease or a three-vessel disease may be viewed as a combination of a side branch and a main epicardial vessel provided they supply different territories; left anterior descending, left circumflex and right coronary artery); 6. Total occluded vessels. One total occluded major epicardial vessel or side branch can be included and targeted as long as one other major vessel has a significant stenosis amenable for SA, provided the age of occlusion is less than one month e.g. recent instability, infarction with ECG changes in the area subtended by the occluded vessel. Patients with total occluded vessels of unknown duration or existing longer than one month and a reference over 1.50 mm should not be included, not even as a third or fourth vessel to be dilated; 7. Significant stenosis has been defined as a stenosis of more than 50% in luminal diameter (in at least one view, on visual interpretation or preferably by QCA); 8. Left ventricular ejection fraction should be at least 30%. Exclusion Criteria: 1. Congestive heart failure; 2. CABG or Percutaneous Coronary Intervention (PCI) procedure; 3. Planned need for major surgery (e.g. valve surgery or resection of aortic or left ventricular aneurysm, carotid end-arterectomy, abdominal aortic aneurysm surgery etc.); 4. Congenital heart disease; 5. Transmural myocardial infarction within the previous seven days and CK has not returned to normal; 6. Chest pain lasting longer than 30 minutes within 12 hours pre-procedure, if CK enzymes positive (≥ 2x the normal upper limit). 7. History of any cerebrovascular accident; 8. Left main stenosis of 50% or more; 9. Intention to treat more than 1 totally occluded major epicardial vessel; 10. Single vessel (single territory) disease.