The aim of the study is to compare the clinical efficacy of three types of plasma secured on the viral level either by quarantine or by chemical treatment in patients undergoing liver transplantation.
Three types of plasma are transfused in bleeding patients undergoing liver transplantation: * quarantined plasma, * methylene blue treated plasma, * solvent/detergent plasma. The main purpose is to show that the volume of methylene blue treated plasma consumed intraoperatively is equivalent to that of the 2 other types of plasma. In addition, the correction of coagulation abnormalities are studied.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
300
transfusion of more than 15 mL/Kg of plasma
EFS
Paris, France
Volume of transfused plasma during surgery
Time frame: 5 years
correction of coagulation abnormalities
Time frame: 5 years
immediate and delayed adverse events
Time frame: 15 days
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