The purpose of this study is to determine whether a combination therapy with angiotensin-converting enzyme (ACE)-inhibitors and angiotensin receptor blockers reduces the arterial stiffness assessed by applantiontonometry more than a single treatment in kidney patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
24 weeks of treatment with Candesartan in incremental doses (4,8,16 mg), where Enalapril is added in incremental doses (5,10 and 20 mg)the last 8 weeks.
24 weeks of treatment with Enalapril in incremental doses (5, 10, 20 mg), where Candesartan is added in incremental doses (4,8,16 mg) in the last 8 weeks.
8 weeks of treatment with Candesartan in incremental doses (4,8,16 mg), followed by 8 weeks of treatment with Enalapril in incremental doses (/5,10,20 mg). The treatment in the last 8 out of the 24 weeks is a combination of Candesartan in incremental doses (4,8,16 mg) and Enalapril 20 mg.
Dept. of Nephrology, Herlev University Hospital
Herlev, Denmark
RECRUITINGpulse wave velocity (aortic and brachial)
Time frame: 0, 8, 16 and 24 weeks after start of intervention
augmentation index
Time frame: 0, 8, 16 and 24 weeks after start of intervention
blood pressure (brachial and aortic)
Time frame: 0, 8, 16 and 24 weeks after start of intervention
buckbergs index
Time frame: 0, 8, 16 and 24 weeks after start of interven
time to reflection
Time frame: 0, 8, 16 and 24 weeks after start of interven
pulse pressure
Time frame: 0, 8, 16 and 24 weeks after start of interven
change in glomerular filtration rate (GFR)
Time frame: 0, 8, 16 and 24 weeks after start of interven
blood parameters
Time frame: at start of intervention and after each 2.5 - 3.week in the study period
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8 weeks of treatment with Enalapril in incremental doses (5,10,20 mg), followed by 8 weeks of treatment with Candesartan (4,8,16 mg). The treatment in the last 8 out of the 24 weeks is a combination of Candesartan 16 mg and Enalapril in incremental doses (5,10,20 mg)