Patients scheduled for primary hip replacement needs postoperative pain treatment, i.e. morphine. Morphine has side-effects: nausea, vomiting, sedation and dizziness. These side-effects are unpleasant for the patients and sometimes keeps them at bed longer time than needed. We investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine.
The effect on postoperative pain of the combination of preoperative gabapentin 1200 mg + dexamethasone 8 mg + ketamine 0.15mg/kg versus placebo is investigated on patients having a hip alloplastic operation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
48
Comparing analgesic effect of gabapentin 1200 mg + dexamethasone 8 mg + ketamine 0.15 mg/kg
Matching placebo
Operations og Anæstesiologisk afd. Y, KAS Glostrup
Glostrup Municipality, Denmark
Anæstesiafdelingen, Herning Centralsygehus
Herning, Denmark
The total amount of morphine needed postoperatively from 0-4h; and 0-24h, administered by a patient controlled pain treatment.(PCA)
Time frame: 0-24h
Pain score (VAS)= at rest and at mobilisation.
Time frame: 0-24h
Postoperative Nausea and vomiting.
Time frame: 0-24h
Dizziness
Time frame: 0-24h
Sedation
Time frame: 0-24h
Nightmare and hallucinations.
Time frame: 0-24h
All measurements are taken at 2,4 and 24 h postoperatively.
Time frame: 0-24h
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