Study for Treatment of Moderate or Severe, Periodic, "Cyclic", Breast Pain

Inclusion Criteria: * History of clinical breast pain. * Documentation of 6 or more sequential days of moderate or severe pain by patient daily diary. * Conservative measures such as local heat, non-prescription analgesics, and properly fitted garments are not effective for the treatment of symptoms * Euthyroid with no prior history of thyroid disease. * Premenopausal female between the ages of 18 and 50. * The presence of at least one palpable structure (nodules, cysts) and involvement (diffuse nodularity or breast thickening) of at least 25% of at least one breast surface. Exclusion Criteria: * History of thyroid disease * Non-cyclic breast pain * Treatment with gonadotropin releasing hormone (GnRH) agonist, Danocrine, tamoxifen, raloxifene, or bromocriptine within three months of starting the trial * Initiation or change of any hormonal therapy within 6 months of enrollment; including birth control pills, hormone replacement therapy, any progestin including Norplant or Depo-Provera; * Current treatment with iodine or iodine-containing medications or diagnostics * Known hypersensitivity to iodine-containing products * Breast implants; * Oophorectomy (complete or partial) * Uncontrolled hypertension; * Breast biopsy breast biopsy within two months of screening; or expectation of a breast biopsy during the study for a suspicious mass present at baseline; * Pregnant women or nursing mothers * History of malignancy within the previous 5 years other than basal cell or squamous cell carcinoma of the skin * History of breast cancer