Fractionated Dosing Study: Study to Evaluate Darbepoetin Alfa for the Treatment of Anemia in Subjects With Non-Myeloid Malignancies

Inclusion Criteria: * Non-myeloid malignancy * Currently receiving 3-week cyclic chemotherapy treatment with a minimum of 2 additional cycles of chemotherapy planned at the time of enrollment * Anemia predominately due to cancer or chemotherapy (Hb \>= 9.0 and \< 11.0 g/dL) at the time of screening * 18 years of age or older at the time of screening * Eastern Cooperative Oncology Group (ECOG) score 0-2 * Adequate liver and kidney function Exclusion Criteria: * Known primary hematologic disorder, which could cause anemia, other than non-myeloid malignancies * History of chronic myeloid leukemia (CML), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), acute lymphocytic leukemia (ALL), hairy cell leukemia, Burkitt's lymphoma, or lymphoblastic lymphoma * Serum folate \<= 2.0 ng/mL or vitamin B12 \<= 200 pg/mL at screening (anemia related to nutritional deficiencies) * Iron deficiency \[transferrin saturation (TSAT) \< 15% and serum ferritin \< 10 ng/mL\] at screening * Other diagnoses not related to cancer or chemotherapy, which cause anemia (ie, hemolysis, bleeding, sickle cell anemia) * Clinically significant inflammatory disease as determined by the investigator (eg, rheumatoid arthritis, Crohn's disease) * Clinically significant co-morbid medical or psychiatric conditions that may impact subject safety or confound the ability to evaluate study endpoint as determined by the investigator * Unstable or uncontrolled cardiac disease or condition (ie, angina, congestive heart failure, or cardiac arrhythmia) * Diastolic blood pressure \> 100 mmHg at screening * Known hypersensitivity of erythropoietic-stimulating proteins (ESPs) or any excipients * Known history of pure red cell aplasia * Known positive antibody response to an ESP * Use of investigational agents not approved or any indication during the previous 30 days prior to enrollment * ESP therapy (i.e., recombinant human erythropoietin \[rHuEPO\] or darbepoetin alfa) within 21 days prior to screening or between screening and the first dose of study drug * RBC transfusion(s) within 21 days prior to screening * Pregnant or breast-feeding women - Previously enrolled in this study * Known to be HIV, hepatitis B or C positive * Any disorder that would compromise the ability of the subject to give written informed consent and comply with study requirements and procedures