Immune Responses to BCG Vaccination in Malawi and the UK

London School of Hygiene and Tropical Medicine

Overview

BCG vaccination has been found to provide greater protection against TB in the UK than in Malawi. This study compares immune responses in BCG-vaccinated and unvaccinated teenagers and young adults in Malawi and in the UK.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Conditions

Immunity, Cellular Hypersensitivity, Delayed Type

Interventions

BCGBIOLOGICAL

Eligibility

Sex: ALLMin age: 12 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BCG unvaccinated * HIV negative * Not pregnant * Informed Consent Exclusion Criteria: * HIV positive * Pregnant * Seriously ill

Locations (2)

Karonga Prevention Study

Chilumba, Karonga District, Malawi

Redbridge and Waltham Forest Primary Care Trust

Ilford, Essex, United Kingdom

Outcomes

Primary Outcomes

Delayed-type hypersensitivity

cytokine responses (eg IFNg) to mycobacterial antigens

Secondary Outcomes

scar size

Data from ClinicalTrials.gov

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