Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid

Inclusion Criteria: * Radiological suspicion of a unilocular malignant glioma with distinct ring- or garland-shaped contrast agent-accumulating tumour structures and a core of reduced intensity in the MRI (central necroses) with no significant non-staining tumour tissue (exclusion of a secondary malignant glioma). * Indication for surgical tumour resection. If radical resection is planned, the location of the contrast agent-accumulating tumour should allow complete resection. * First operation of the tumour, no other tumour-specific pretreatment * Karnofsky at least 70 % * Patient's written informed consent * Age 18-72 years Exclusion Criteria: * Tumour location in the midline, basal ganglia, cerebellum or brain stem * More than one contrast agent-accumulating lesion unrelated to the primary tumour or extracerebral metastases * Porphyria, hypersensitivity to porphyrins * Renal insufficiency: Creatinine \> 2.0 mg/dl * Hepatic insufficiency: Bilirubin \> 3 mg/dl * Quick test \< 60 % * gamma-GT \> 70 U/I * Malignancies other than basaliomas * Existing or planned pregnancy or lactation, or inadequate contraception * Simultaneous participation in another clinical trial or participation in another clinical trial in the 30 days preceding randomisation