Evaluation of Chemotherapy Prior to Surgery With or Without Zometa for Women With Locally Advanced Breast Cancer

Inclusion Criteria: * Newly diagnosed primary invasive ductal or invasive lobular breast adenocarcinoma * Tumor classified as clinically large T2 (2-5 cm), T3, T4 or any T with N1, N2 * Prior malignancies: limited to curatively treated basal or squamous carcinoma of the skin or history of previous malignancies, treated and now \> 5 years disease free * \>= 18 years of age * Normal left ventricular function by echocardiogram or radioventriculogram * Karnofsky Performance \>= 70 Exclusion Criteria: * No evidence of distant metastasis present by CT, Bone scan, or physical exam * If the bone scan or CT scans demonstrate indeterminate lesions, the nature of these lesions may be further clarified by additional testing such as PET or MRI * No current treatment with Zometa or other bisphosphonates * No serious functional disorders of the liver or kidneys: * Serum Creatinine \<=2 * ALT/AST/ALK Phos \<= 1.5 x upper limit of institutional normal. * Bili \<= 1.5 x upper limit of institutional normal. * Currently not pregnant