High Doses of Candesartan Cilexetil on the Reduction of Proteinuria

Inclusion Criteria: * Informed consent * Stable hypertension defined as no new antihypertensive medication started within 6 weeks of Visit 1 * Minimum 6-month history of hypertension and primary glomerular disease * Hypertensive nephrosclerosis * Diabetic nephropathy with stable proteinuria as defined by ≥ 1g/24 hours on more than one occasion within 6 months prior to Visit 1 Exclusion Criteria: * Persistent hypertension * New anti-hypertensive medications started within 6 weeks of Visit 1 * Significant cardiac disease or Liver disease * Females of childbearing potential without reliable contraception * Pregnant women and women who are breast-feeding