Hemostatic Matrix in Endoscopic Sinus Surgery

Inclusion Criteria: * Patients who are 18 years or older. * Patients undergoing elective primary or re-do endoscopic sinus surgery for chronic sinusitis with bleeding surface requiring an adjunct to achieve hemostasis. * Patients must be willing and capable of cooperating to the extent and degree required by the protocol and sign the IRB approved Informed Consent Form prior to any participation in the study. Exclusion Criteria: * Patients with bleeding diathesis, pathologic coagulopathy, systemic disorders, inflammatory conditions (other than chronic sinusitis or nasal polyposis) or autoimmune, immunodeficiency diseases or any other disorder that may interfere with hemostasis. * Patients with severe (brisk or forceful) bleeding site(s). * Patients undergoing urgent or emergency endoscopic sinus surgery. * Patients with bronchial asthma who have aspirin intolerance. * Patients with diffuse polyposis that would require chronic oral steroids or patients on chemotherapeutic agents that might delay healing (short term pulse steroid therapy and topical steroids are acceptable). * Patients who have used anticoagulant, antiplatelet or nonsteroidal anti-inflammatory analgesic (NSAID) within 7 days prior to surgery. * Patients who are morbidly obese (Body Mass Index \> 35). * Patients with acute local infection at the operative side. * Patients who are current alcohol and/or drug abusers. * Patients with neoplasm, craniofacial abnormalities (e.g. cleft palate), or sleep apnea using nasal CPAP, or patients that may require a Lothrop procedure. * Female patients who are pregnant or nursing. * Patients who have uncontrolled diabetes mellitus (blood glucose levels \>400 mg/dl) as determined by the Investigator based on medical history. * Patients who have participated in another investigational drug or device research within 30 days of enrollment. * Patients with known antibodies to bovine thrombin preparations, sensitivities or religious prohibitions to porcine gelatin or bovine components.