Study Evaluating rhMBP-2/CPM in Open Wedge Osteotomies

Inclusion Criteria: * Male or female subjects 45 to 70 years of age * Within 96 hours prior to dosing, the subject underwent a successful open wedge tibial osteotomy to correct medial compartment OA of the knee. * Female subjects of childbearing potential must have a negative pregnancy test (hospital acceptable test), upon hospitalization for OWO and agree to use medically approved contraception for the duration of the study. Other inclusion applies. Exclusion Criteria: * Subjects with pre-existing conditions of the knee or tibia that would confound an interpretation of results. * Subjects for whom surgery in the opposite knee is planned during the 6 months of follow-up. * Subjects with a history of malignancy or radiotherapy or chemotherapy for malignancy within the past 5 years, except subjects with a history of basal skin carcinoma. Other exclusion applies.