Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis

Osaka City University200 enrolled

Overview

The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may contribute to the pathogenesis of ONFH. The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Femur Head Necrosis

Eligibility

Sex: ALLMin age: 14 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of avascular necrosis of the femur Exclusion Criteria: * Old age (\> 70 years) * Severe hepatic or renal dysfunction * Heart disease * Current use of known CYP3A-inducing or -inhibiting drugs * Morbid obesity

Locations (1)

Graduate School of Medicine, Osaka City University

Osaka, Osaka, Japan

Data from ClinicalTrials.gov

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