Outcomes of Patients Not Responding to Antibiotics in the Community

Inclusion Criteria: Patients who have failed to respond to at least three (ABECB and CAP) or five (AMS/ABRS/AECRS) days of macrolide or b-lactam therapy meeting all of the protocol criteria for acute bacterial exacerbations on chronic bronchitis(ABECB), community acquired pneumonia(CAP) and acute maxillary sinusitis(AMS) will be eligible for enrollment. All patients, whether enrolled retrospectively or concurrently, must have a positive culture. The pathogenic bacteria must be identified by a local laboratory and have a known susceptibility to the antibiotic class the patient failed to respond to (i.e. macrolide or b-lactam). The isolate must be sent to the Study Coordinating Center for precise MIC determination. Exclusion Criteria: Patients presenting with any of the following will not be included in the study: 1. Life expectancy \<3 months from underlying disease 2. Underlying lung carcinoma 3. Cystic fibrosis