The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy. Patients will be randomized to either conventional colonoscopy or chromocolonoscopy, where the entire colon will be sprayed with indigocarmine dye and examined in the usual manner. The primary outcome will be the total number of adenomas detected, with special attention to the subgroup of flat and depressed lesions. To promote the generalizability of the results, neoplasms will be described according to standard Western and Japanese classification schemes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
792
Indigocarmine dye applied to entire colon to highlight mucosal detail and enhance detection of flat lesions.
Indiana University
Indianapolis, Indiana, United States
Roudebush VA Medical Center
Indianapolis, Indiana, United States
SUNY Stony Brook
Stony Brook, New York, United States
Prevalence of adenomas detected by chromocolonoscopy versus standard colonoscopy.
Time frame: Cross-sectional prevalence of adenomas between the 2 study groups
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