Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer

Inclusion Criteria: * Untreated, stage IIIB with pleural effusion * Untreated, Stage IV, non-small cell lung cancer * Recurrent after surgery if no previous radiation therapy or chemotherapy were administered as part of their primary treatment, except for palliative radiotherapy * 18 years of age or older * ECOG PS 0, 1 or 2 * At Least one target lesion according to the RECIST Criteria * Adequate organ and marrow function Exclusion Criteria: * Previous cancer history unless they have had curative treatment completed at least 5 years prior to entry. * No previous radiotherapy, chemotherapy or immunotherapy for NSCLC, except for radiation therapy to the brain to control metastasis, bone to control pain, or lung to relieve bronchial obstruction. * No radiation therapy for any previous cancer to more than 25% of bone marrow. * Uncontrolled, intercurrent illness * Non-study corticosteroids * Pregnant women * Peripheral neuropathy greater than grade 1 * Uncontrolled seizures, central nervous system disorders * Major surgery within 4 weeks of the start of study treatment * Lack of complete recovery from major surgery. * Glaucoma * Lack of physical integrity of upper gastrointestinal tract, inability to swallow tablets * Severe acquired or hereditary immunodeficiency * Patients with brain metastases must receive definitive treatment (radiation, surgery or both) and be clinically and radiologically stable for 4 weeks \& off corticosteroids for at least 2 weeks prior to randomization.