Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients

Johns Hopkins University

Overview

The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Conditions

Familial Adenomatous Polyposis

Interventions

curcuminDRUG

curcumin 500 mg by mouth, three times a day for 9 months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Familial adenomatous polyposis * 18 years of age or older * 5 or more adenomas of colorectum or ileum Exclusion Criteria: * Female patient of child bearing age not on effective birth control pills * Pregnant women * White blood cell (WBC) count less than 4000 * Platelets (Plts) less than 100,000 * Blood urea nitrogen (BUN) greater than 25 * Creatine greater than 1.5 * Patients unable to stop non-steroidal anti-inflammatory drugs (NSAIDs) during duration of trial * Malignancy * Patient with active bacterial infections of gastroesophageal reflux disease or peptic ulcer disease * Patient on warfarin or anti-platelet drugs

Outcomes

Primary Outcomes

polyp number and size

Time frame: one year

Secondary Outcomes

side effects and medication compliance

Time frame: one year

Data from ClinicalTrials.gov

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