Comparison Trial of Letrozole to Anastrozole in the Adjuvant Treatment of Postmenopausal Women With Hormone Receptor and Node Positive Breast Cancer

Overall Survival

Overall survival was defined as the time from the date of randomization to the date of death from any cause.

Time frame: 84 months

Time to Development of Distant Metastases

Time to development of distant metastases was defined as the time from date of randomization to the date of the first development of any recurrent or metastatic disease in sites other than the local mastectomy scar, the ipsilateral breast in case of breast conservation or the contra lateral breast.

Time frame: 84 months

Time to Development of Contra Lateral Breast Cancer

Time to development of contra lateral breast cancer was defined as the time from the date of randomization to the date of the first development of any disease in the contra lateral breast.

Time frame: 84 months

Distant Disease-free Survival

Distant disease-free survival was defined as the time from date of randomization to the date of the first development of any relapse at a distant site or death from any cause.

Time frame: 84 months

Change From Baseline in Serum Lipid Profiles

Total cholesterol was analyzed to assess the impact on serum lipids profiles. The adjusted means was calculated.

Time frame: baseline, 6, 12, 24, 36, 48 and 60 months