NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS)

Inclusion Criteria: * Advanced, recurrent, or metastatic solid tumors * TS overexpression (\> 4 by reverse transcription polymerase chain reaction \[RT-PCR\]) in archival and fresh samples * Suitable for experimental monotherapy * Measurable disease Exclusion Criteria: * Tumors that cannot be biopsied or with low level of TS expression * Requirement for concomitant anticancer therapy * Treatment with another investigational product within 30 days of study entry * Pregnant or lactating women * Active or uncontrolled serious bacterial, viral, fungal, or parasitic infection. * HIV infection * Clinically apparent meningeal or central nervous system (CNS) metastases or carcinomatous meningitis