Peri-Operative Morbidity and Quality of Life After Coronary Artery Bypass Graft (CABG)

Weill Medical College of Cornell University248 enrolled

Overview

It is the long term objective of this study to preserve or improve the quality of life and to prevent deterioration in physical and mental function following myocardial revascularization among bypass surgery patients.

The objective of this study is to compare the efficacy of two strategies of intra-operative hemodynamic management in preventing peri-operative cardiac, cognitive and neurologic morbidity and mortality and postoperative deterioration in the patient's quality of life.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

248

Conditions

Coronary Artery Bypass Graft Surgery

Interventions

Regulating Mean Arterial Pressure during cardiopulmonary bypassPROCEDURE

Patients were randomized to one of two groups. In the first group (Low) the goal was to maintain MAP between 50-60 mm Hg during CPB. In the second group (High), the goal was to maintain MAP between 80-100 mm Hg. In both groups, CPB flow was held constant at 1.6 L/min/M2 (cool) and 2.4 L/min/M2 (warm) and vasoactive drugs (nitroglycerin or phenylephrine) were used to maintain MAP in the desired range. MAP was controlled in this fashion from the onset of CPB through separation from CPB began.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients had to be undergoing elective CABG, without concomitant valve or other cardiac surgery. 2. Patients also had to be able to perform the neuropsychologic tests, and to provide informed consent. Exclusion Criteria: 1. Patients who refused to participate in the study. 2. Patients who live too far away from NYC to be able to come back for follow up at six months post-operatively. 3. Patients who had either valvular replacement and aortic amd mitral an aneurysm repair, or other cardiothoracic surgery. 4. Patients who were unable to complete the neuropsychologic test. 5. Patient who were part of another CABG study.

Locations (1)

New York Presbyterian Hospital-Weill Cornell Medical College

New York, New York, United States