In this study the investigators want to determine if treatment with haloperidol direct post-operatively after acute hip surgery in high risk patients protects against developing a post-operative delirium.
A post-operative delirium is a serious and frequent (35-65%) complication with high morbidity and mortality in high risk patients. In this study we investigate whether we can prevent a delirium from occuring after surgery in patients with a hip fracture of 75 years of age and older. It's a randomised double-blind single centre placebo-controlled study of haloperidol versus placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
220
Haloperidol 1mg twice daily during 72hours
Placebo 1mg twice daily during 72hours
Bronovo Hospital
The Hague, South Holland, Netherlands
Incidence of post-operative delirium
Time frame: 72 hours post surgery
Length of stay
Time frame: days
Complications
Time frame: during hospitalization
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