Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium

Copenhagen University Hospital at Herlev60 enrolled

Overview

Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes in many tissues. The goal of this study is to illuminate bladder tissue production of NO in individuals with PBS and healthy individuals, by quantification of NO and NO-enzyme expression by different molecular biological methods.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Interstitial Cystitis Bladder Diseases Urinary Incontinence

Interventions

Tissue examination for protein- and mRNA-expression of NOPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * PBS/IC according to International Continence Society (ICS) * Cystoscopy with bladder distension and deep biopsies within last 5 years * Cystometry within last 5 years * Normal urine culture within last month Inclusion Criteria (for control group): * Benign non-invasive bladder disease * No PBS/IC * Normal urine culture * No functional bladder disease of known nature (ex. infravesical obstruction) Exclusion Criteria: * Age under 18 years * Inability to understand instructions * Pregnancy and lactation

Data from ClinicalTrials.gov

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Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium

Overview

Conditions

Interventions

Eligibility

Locations (1)