Topical Gel Anti-Fungal Agent for Tinea Unguium

Inclusion Criteria: * clinical diagnosis of distal subungual tinuea unguium of one great toenail. * between 20 - 65% infected area for target nail * 2 mm of clear nail proximally on target nail * positive dermatophyte culture and positive KOH test * able to sign informed consent * understand requirements of study * females must be post-menopausal or agree to use approved contraceptives throughout the study Exclusion Criteria: * patients with nails infected with organisms other than dermatophytes * patients with proximal subungual tinea unguium * patients with spikes of disease extending to nail matrix * patients with more than 5 infected nails * patients with confounding problems/ abnormalities of target nail * patients with screening lab values more than 20% of normal * patients with known hypersensitivity to test material components * patients requiring systemic medications that may interfere with study * patients with a poor history of compliance with study requirements